Epistasis and decanalization shape gene expression variability in humans via distinct modes of action
نویسندگان
چکیده
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. Institute for Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA. Interdisciplinary Program of Genetics, Texas A&M University, College Station, Texas, USA
منابع مشابه
Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action.
Increasing evidence shows that phenotypic variance is genetically determined, but the underlying mechanisms of genetic control over the variance remain obscure. Here, we conducted variance-association mapping analyses to identify expression variability QTLs (evQTLs), i.e. genomic loci associated with gene expression variance, in humans. We discovered that common genetic variants may contribute ...
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تاریخ انتشار 2015